Khadeejah

Prophet Muhammad married her when he was twenty-five, while she had reached the age of forty. She was a widow, twice married. He was at the peak of his youth. Impressed by Muhammad’s honesty and moral character, she send a relative to propose marriage. They were married for twenty five years until her death. Through every persecution, Khadeejah was his sole companion and helper. Khadeejah, along with Aisha, played a major contribution in the establishment and spread of the Islamic civilization. Khadeejah bore four daughters with the Prophet: Zainab, Umm Kulthoom, Ruqayya, and Fatima. All four grew to maturity and accepted Islam. They all died in the lifetime of their father, except Fatima who died six months after the Prophet. Khadeejah also bore two sons, Qasim and Abdullah, both of whom died at an early age.
source:
islamkingdom